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Jonas Vingegaard abandons Tour de France with broken collarbone

Jonas Vingegaard has crashed out of the Tour de France, breaking his collarbone just before a final climb. His Visma-Lease a Bike team does not attribute the fall to a night-time doping control that occurred before the stage, stating the rider felt good.

How much do disruptive night-time doping controls really affect a Grand Tour contender's performance and safety, regardless of what Visma-Lease a Bike claims?